Lyme Disease is an infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Early symptoms may include fever, headache and fatigue.
A rash occurs in 70–80% of infected persons at the site of the tick bite after a delay of 3–30 days (average is about 7 days), and may or may not appear as the well-publicized bull's-eye (erythema migrans).
The rash is only rarely painful or itchy, although it may be warm to the touch. About 20–30% of infected persons do not experience a rash. .
Left untreated, later symptoms may involve the joints, heart, and central nervous system. In most cases, the infection and its symptoms are eliminated by antibiotics, especially if the illness is treated early.
If untreated, the bacteria may persist in the body for months or even years, despite the production of B. burgdorferi antibodies by the immune system. The spirochetes may avoid the immune response by decreasing expression of surface proteins that are targeted by antibodies, antigenic variation of the VlsE surface protein, inactivating key immune components such as complement, and hiding in the extracellular matrix, which may interfere with the function of immune factors.
What does T-Cell Modulator do?
Immune tolerance is the process by which the body naturally does not launch an immune system attack on its own tissues. Immune tolerance therapies seeks to reset the immune system so that the body stops mistakenly attacking its own organs or cells in autoimmune disease or accepts foreign tissue in organ transplantation. A brief treatment should then reduce or eliminate the need for lifelong immunosuppression and the chances of attendant side effects, in the case of transplantation, or preserve the body's own function, at least in part, in cases such as diabetes, Lupus, Arthritis, Allergies, Hepatitis, Lyme Disease, Herpes, HIV or other autoimmune disorders.
T-Cell Modulator is able to recognize a specific receptor on the surface of dendritic cells (TLR4 receptor) activating them until maturity producing a signal that activates the TH1 and TH2 lymphocytes.
TH1 activation causes the release of substances called interleukins and activates lymphocytes NK (natural killer) cell signal releasing substances such as interferon gamma (IFN γ), which has a myriad of functions (macrophage activation, viral replication inhibitor, anti-inflammatory activity, etc.).
Activation of TH2 causes the release of more cytokines that have a large number of regulatory functions, including inhibiting the formation of cytokines, decreasing the effects of the disease.