Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage.
One manifestation of SLE is abnormalities in apoptosis, a type of programmed cell death in which aging or damaged cells are neatly disposed of as a part of normal growth or functioning.
In SLE, the body's immune system produces antibodies against itself, particularly against proteins in the cell nucleus. SLE can be triggered by environmental factors that are unknown.
Cellular immunity aberrations in patients with SLE are underscored by an abnormal receptor–mediated lymphocyte signal pathway.
What are T-Cell Modulators?
Immune tolerance is the process by which the body naturally does not launch an immune system attack on its own tissues. Immune tolerance therapies seeks to reset the immune system so that the body stops mistakenly attacking its own organs or cells in autoimmune disease or accepts foreign tissue in organ transplantation. A brief treatment should then reduce or eliminate the need for lifelong immunosuppression and the chances of attendant side effects, in the case of transplantation, or preserve the body's own function, at least in part, in cases such as diabetes, Lupus, Arthritis, Allergies, Hepatitis, Lyme Disease, Herpes, HIV or other autoimmune disorders.
T-Cell Modulator is a leukocyte extract manufactured by a proprietary methodology,
described in part in the patented our own T-Cell Modulator which is a leukocyte.
Therapeutic effects of T-Cell Modulator have previously been demonstrated in
immunologically mediated conditions, as well as oncology.
T-Cell Modulator are able to recognize a specific receptor on the surface of dendritic cells (TLR4 receptor) activating them until maturity producing a signal that activates the TH1 and TH2 lymphocytes.
TH1 activation causes the release of substances called interleukins and activates lymphocytes NK (natural killer) cell signal releasing substances such as interferon gamma (IFN γ), which has a myriad of functions (macrophage activation, viral replication inhibitor, anti-inflammatory activity, etc.).
Activation of TH2 causes the release of more cytokines that have a large number of regulatory functions, including inhibiting the formation of cytokines, decreasing both inflammatory effects and allergic reactions.
Immune modulation has a dual function, specifically stimulation on the one hand and a regulation on the other. This is a characteristic of an optimized immune system. Having a tool like T-Cell Modulator at our disposal, helps us achieve a renewed and active Immune system.