Hepatitis C virus (HCV) induces inflammatory signals, leading to hepatitis, hepatocellular carcinomas, and lymphomas. Several receptors have been studied in order to determine the exact effects and mechanisms that dictate how HCV affects the immune system and the liver. Recent findings have directed researchers toward Toll-Like receptors (TLR’s).
What are Toll-Like receptors (TLR’s)?
Among all of the TLRs (TLRs 1 to 10) examined, only TLR4 showed an altered after HCV infection. HCV infection significantly increased beta interferon (IFN-beta) and interleukin-6 (IL-6) secretion from B cells. This contributes to the host's diminished innate immune responses and inability to fight off the infection and preserve healthy liver tissue.
How does T-Cell Modulator work for Hepatitis C patients ??
T Cell modulators bind specifically to TLR4 receptors and modulate cytokine production. It stimulates the production of Interferon gamma and reduces the production of both IFN-beta and IL-6, thereby directly influencing and inhibiting the substances that don’t allow the appropriate immune response to infection, and also inhibit tissue repair.
By implementing a T cell Modulator therapy, you essentially eliminate the virus’ defense mechanism and prevent any further damage, all the while allowing your own immune system to effectively and efficiently deal with the infection and promote better liver function.