Alzheimer’s disease (AD) is the most common cause of dementia worldwide. The development and evolution of this neurodegenerative disease, currently without curative treatment, is associated with the accumulation of amyloid β (Aβ) in brain tissue and it’s blood vessels. AD patients are unable to clear this toxic peptide, leading to Aβ accumulation in their brains and, presumably, the pathology associated with this devastating disease.
Compounds that stimulate the immune system to clear Aβ therefore have great therapeutic potential in AD patients.
How does T-Cell Modulator work for Alzheimer’s patients ?
T-Cell Modulator® is a small polypeptde chain that acts as a Toll-like receptor 4 (TLR4) agonist (activator) and exhibits unique immunomodulatory properties by binding specifically to that receptor and activating it.
This promotes an overall regulatory effect in the immune system by “training” it’s own cells to decrease over-production of certain chemical substances that may activate unwanted effects in other cells, or have toxic effects themselves, all the while increasing the production of chemical substances that activate cells to promote healing, as well as the consumption and clearance of Aβ
Treatment with T-Cell Modulators®, can significantly improve AD-related pathology by leading to a significant reduction in Aβ load in the brain, as well as enhanced cognitive function. T Cell Modulator induces a potent responseby glial cells (immune cells found in the central nervous system) that promotes the clearance and reduction of Aβ, thereby improving patients’ overall quality of life, as well as preventing further damage and allowing for recovery to some extent.